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Larazotide acetate is an investigational oral peptide designed to regulate intestinal epithelial tight junctions. Research has primarily focused on its potential to reduce gluten-related intestinal and gastrointestinal effects in people with celiac disease.
Gopalakrishnan S, Durai M, Kitchens K, et al.
Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012;35(1):86–94.
doi:10.1016/j.peptides.2012.02.015. PMID: 22401908. (PubMed)
Gopalakrishnan S, Tripathi A, Tamiz AP, Alkan SS, Pandey NB.
Larazotide acetate promotes tight junction assembly in epithelial cells. Peptides. 2012;35(1):95–101.
doi:10.1016/j.peptides.2012.02.016. PMID: 22401910. (PubMed)
Kelly CP, Green PHR, Murray JA, et al.
Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther. 2013. PMID: 23163616. (PubMed)
Leffler DA, Kelly CP, Green PHR, et al.
Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology. 2015. PMID: 25683116. (PubMed)
Khaleghi S, Ju JM, Lamba A, Murray JA.
The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate. Ther Adv Gastroenterol. 2016;9(1):37–49.
doi:10.1177/1756283X15616576. PMID: 26770266. (PubMed)
Store refrigerated at 2–8°C, protected from light and moisture. Keep the container tightly closed and avoid excessive temperature cycling.
Shelf Life: 2 years from manufacturing date, provided proper storage recommendations are followed.
Supports intestinal barrier function: Larazotide has been studied for its ability to help regulate tight-junction activity and limit excessive paracellular passage across the intestinal epithelium.
May reduce gluten-related GI symptoms: Clinical trials in people with celiac disease found that certain doses, including 1 mg, reduced gastrointestinal symptoms during controlled gluten exposure.
May reduce gluten-associated immune activation: In one randomized trial, the 1 mg group had a lower increase in anti-tissue-transglutaminase IgA compared with placebo during gluten challenge.
Locally acting: Larazotide is designed to act within the intestinal tract rather than producing substantial systemic exposure.
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